Nitric Acid → HCID 178526747、化合物

反応式

[NH:1]1[C:5]2=[N+:6]([O-:10])[CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.S(=O)(=O)(O)O.O.[N+:17]([O-])([OH:19])=[O:18]>>[N+:17]([C:9]1[CH:8]=[CH:7][N+:6]([O-:10])=[C:5]2[NH:1][CH:2]=[CH:3][C:4]=12)([O-:19])=[O:18]

参加物

反応物 4

HCID 944Nitric Acid

HCID 962Water

HCID 1118Sulfuric Acid

HCID 178526243HCID 178526243、化合物

生成物 1

HCID 178526747HCID 178526747、化合物

反応条件

温度: 70 °C

実験手順

4-Nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide 508 is prepared by dissolving 1H-Pyrrolo[2,3-b]pyridine 7-oxide 507 in nitric acid, followed by the addition of sulfuric acid. Heating (e.g. 70° C.) for one hour, followed by pouring into water provides compound 508, which is isolated by filtration. (Schneller et. al., J. Org. Chem. 1980, 45:4045)