4-Methyl-2-oxovaleric acid → Methyl 4-methyl-2-oxopentanoate

HRID 2261726ノート

反応式

HRID 2261726 の反応式
[CH3:1][CH:2]([CH3:9])[CH2:3][C:4](=[O:8])[C:5]([OH:7])=[O:6].Cl[Si](C)(C)[CH3:12]>CO.COC(OC)(C)C>[CH3:12][O:6][C:5](=[O:7])[C:4](=[O:8])[CH2:3][CH:2]([CH3:9])[CH3:1]

参加物

5

反応物 2

HCID 704-Methyl-2-oxovaleric acidHCID 6397Chlorotrimethylsilane

生成物 1

HCID 546077Methyl 4-methyl-2-oxopentanoate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 64952,2-Dimethoxypropane溶媒

実験手順

To a solution of 4-methyl-2-oxo-pentanoic acid (3.4 g, 26 mmol) in methanol (12 mL) and 2,2-dimethoxypropane (48 mL) is added chlorotrimethylsilane (0.38 mL). The reaction mixture is stirred at ambient temperature overnight. The reaction mixture is concentrated under reduced pressure to give the title compound as an oil, (3.8 g, quant.). 1H NMR (400 MHz, CDCl3): δ 3.86 (s, 3H), 2.72 (d, 2H), 2.16 (m, 1H), 0.96 (d, 6H).

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9c94aee87db64cf4a8fffb905caea73e
出典データセット
uspto-grants-2010_12
特許番号
US07846960B2

反応ノート

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