Formaldehyde → 3-[({6-[4-Isopropyl-2-(2-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-2-methyl-pyridin-3-yl}-methyl-amino)-methyl]-benzoic acid methyl ester

HRID 2261855ノート

反応式

HRID 2261855 の反応式
[CH:1]([C:4]1[CH:8]=[N:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][C:16]([F:19])([F:18])[F:17])[C:5]=1[CH2:20][O:21][C:22]1[N:27]=[C:26]([CH3:28])[C:25]([NH2:29])=[CH:24][CH:23]=1)([CH3:3])[CH3:2].[CH3:30][O:31][C:32](=[O:41])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([CH:39]=O)[CH:34]=1.[B][B][B][B][B][B][B][B][B][B].[CH2:52]=O>CO>[CH3:30][O:31][C:32](=[O:41])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([CH2:39][N:29]([C:25]2[C:26]([CH3:28])=[N:27][C:22]([O:21][CH2:20][C:5]3[N:6]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[O:15][C:16]([F:19])([F:17])[F:18])[N:7]=[CH:8][C:4]=3[CH:1]([CH3:3])[CH3:2])=[CH:23][CH:24]=2)[CH3:52])[CH:34]=1

参加物

6

反応物 4

HCID 712FormaldehydeHCID 639145Methyl 3-formylbenzoateHCID 675280466-[4-Isopropyl-2-(2-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-2-methyl-pyridin-3-ylamineHCID 178419135HCID 178419135、化合物2 回

生成物 1

HCID 675279973-[({6-[4-Isopropyl-2-(2-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-2-methyl-pyridin-3-yl}-methyl-amino)-methyl]-benzoic acid methyl ester収率 69%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To an ambient temperature solution of 6-[4-isopropyl-2-(2-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-2-methyl-pyridin-3-ylamine (100 mg, 0.246 mmol) in MeOH (3 mL) is added 3-formyl-benzoic acid methyl ester (40 mg, 0.246 mmol). The reaction mixture is stirred at room temperature for 10 min. Decaborane (12 mg, 0.0738 mmol) is added and the reaction mixture is stirred at room temperature. After 2 h, formaldehyde (2.0 mL, 37 wt % in water) is added and the reaction mixture is stirred at room temperature for 10 min. Decaborane (12 mg, 0.0738 mmol) is added and the reaction is stirred at room temperature. After 2 h, the reaction mixture is concentrated and the residue is chromatographed (SiO2 40 g, 0% to 20% EtOAc/Hex) to yield the title compound (97 mg, 69%). 1H NMR (400 MHz, DMSO) δ 7.91-7.88 (m, 1H), 7.81 (dt, 1H, J=4.6, 2.5 Hz), 7.63 (s, 1H), 7.59-7.50 (m, 4H), 7.48-7.41 (m, 3H), 6.39 (d, 1H, J=7.9 Hz), 5.13 (s, 2H), 4.00 (s, 2H), 3.82 (s, 3H), 3.03 (sept, 1H, J=6.6 Hz), 2.46 (s, 3H), 2.32 (s, 3H), 1.18 (d, 6H, J=6.6 Hz).

後処理

  1. stirringthe reaction mixture is stirred at room temperature
  2. waitAfter 2 h
  3. stirringthe reaction mixture is stirred at room temperature for 10 min
  4. stirringthe reaction is stirred at room temperature
  5. waitAfter 2 h
  6. concentrationthe reaction mixture is concentrated
  7. customthe residue is chromatographed (SiO2 40 g, 0% to 20% EtOAc/Hex)

出典と根拠

ORDレコード
ord-9b833ea62b2a42efb35766051253fbf6
出典データセット
uspto-grants-2010_12
特許番号
US07846960B2

反応ノート

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