CN([C:7]1[CH:8]=[C:9]([CH:22]=[C:23](Br)[CH:24]=1)[C:10]([NH:12][C@@H](C1C=CC(F)=CC=1)C)=[O:11])S(C)(=O)=O.CC(C)=O.C(NC(C)C)(C)C.C[Si](C#C)(C)C>CCOC(C)=O.[Cu]I.[Pd].C(P(C(C)(C)C)C(C)(C)C)(C)(C)C.C(P(C(C)(C)C)C(C)(C)C)(C)(C)C.C(Cl)(Cl)Cl.[Pd].[Pd].O1CCOCC1>[C:10]([NH2:12])(=[O:11])[C:9]1[CH:22]=[CH:23][CH:24]=[CH:7][CH:8]=1To a solution of 3-(N-methyl-N-(methylsulfonyl)amino)-5-bromo-N—((R)-1-(4-fluorophenyl)ethyl)benzamide (200 mg, 0.46 mmol), copper(I)iodide (3.6 mg, 0.019 mmol), bis(tri-t-butylphosphine) palladium (0) (14 mg, 0.028 mmol) and tris(dibenzylide acetone) dipalladium (0) chloroform adduct (14.2 mg, 0.014 mmol) in 0.5 mL degassed dioxane was added diisopropylamine (0.084 mL, 0.60 mmol) and (trimethylsilyl)acetylene (0.085 mL, 0.60 mmol). The reaction was stirred at rt overnight and then heated to 60° C. for an additional night. The mixture was diluted with EtOAc and filtered through celite. Concentration and flash chromatography (10-50% EtOAc/hexanes) gave 3-(N-methyl-N-(methylsulfonyl)amino)-N—((R)-1-(4-fluorophenyl)ethyl)-5-(2-trimethylsilyl)ethynyl)benzamide. 1H NMR (CDCl3) δ 7.77 (m, 1H), 7.67 (m, 1H), 7.61 (m, 1H), 7.35 (m, 2H), 7.05 (m, 2H), 6.28 (d, J=7.3 Hz, 1H), 5.29 (m, 1H), 3.33 (s, 3H), 2.86 (s, 3H), 1.60 (d, J=7.0 Hz, 3H), 0.26 (s, 9H).
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