Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate → Methyl 2-[(3,4-diaminophenyl)carbonyl]benzoate

HRID 2261926ノート

反応式

HRID 2261926 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[O:9])=[CH:4][C:3]=1[N+:20]([O-])=O>[Pd]>[NH2:20][C:3]1[CH:4]=[C:5]([C:8]([C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[O:9])[CH:6]=[CH:7][C:2]=1[NH2:1]

参加物

3

反応物 1

HCID 14994663Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate

生成物 1

HCID 67044285Methyl 2-[(3,4-diaminophenyl)carbonyl]benzoate収率 98.5%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A solution of methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate (420 mg, 1.39 mmol) in a mixture of terahydrofuran-ethyl acetate (1:1, 20 mL) was hydrogenated over 10% Pd—C (10 mg) for 18 h. The catalyst removed by filtration and the filtrate concentrated to give methyl 2-[(3,4-diaminophenyl)carbonyl]benzoate (370 mg, 98%) as a brown powder. MS (EI) for C15H14N2O3: 293 (MNa+).

後処理

  1. customThe catalyst removed by filtration
  2. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-82b44287e45e489ca1fbc3c6930b8849
出典データセット
uspto-grants-2010_12
特許番号
US07846959B2

反応ノート

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