3-Ethynyl-4-fluoroaniline → 3-Ethyl-4-fluoroaniline

HRID 2261989ノート

反応式

HRID 2261989 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[F:10])[NH2:6])#[CH:2].[H][H]>C(OCC)(=O)C.[Pd]>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[F:10])[NH2:6])[CH3:2]

参加物

5

反応物 2

HCID 126873623-Ethynyl-4-fluoroanilineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 207143403-Ethyl-4-fluoroaniline収率 69%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 3-ethynyl-4-fluoroaniline (220 mg, 1.62 mmol) in ethyl acetate (10 mL) was added 10% palladium on carbon (wet). The resulting mixture was subjected to an atmosphere of hydrogen for approximately 1 h. The palladium on carbon was removed by filtration through celite. The filtrate was concentrated in vacuo to provide 3-ethyl-4-fluoroaniline (154 mg, 1.11 mmol, 69% yield) as a brown oil. 1H NMR (400 MHz, CDCl3): 6.77 (dd, 1H), 6.50 (dd, 1H), 6.45-6.41 (m, 1H), 3.47 (br s, 2H), 2.57 (q, 2H), 1.19 (t, 3H); MS (EI) for C8H10FN: 140 (MH+).

後処理

  1. customThe palladium on carbon was removed by filtration through celite
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-4cab646189ff45ad93b57e2a2fc38d0d
出典データセット
uspto-grants-2010_12
特許番号
US07846959B2

反応ノート

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