Triethylamine → tert-Butyl 3-methanesulfonamidopyrrolidine-1-carboxylate

HRID 2262127ノート

反応式

HRID 2262127 の反応式
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>CC#N>[C:10]([O:9][C:7]([N:4]1[CH2:5][CH2:6][CH:2]([NH:1][S:22]([CH3:21])(=[O:24])=[O:23])[CH2:3]1)=[O:8])([CH3:13])([CH3:12])[CH3:11]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27563701-Boc-3-aminopyrrolidine

生成物 1

HCID 67189774tert-Butyl 3-methanesulfonamidopyrrolidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of (+/−)-3-amino-1N—BOC-pyrrolidine (0.5 g) in MeCN (10 mL) was added triethylamine (0.41 mL) then methanesulfonyl chloride (0.22 mL). The mixture was stirred for 2.5 h. An aqueous work-up followed by purification on silica gave 3-methanesulfonylamino-pyrrolidine-1-carboxylic acid tert-butyl ester (0.49 g).

後処理

  1. customAn aqueous work-up followed by purification on silica

出典と根拠

ORDレコード
ord-396bd5aa34ad4feca4e523798be0e3dd
出典データセット
uspto-grants-2010_12
特許番号
US07846929B2

反応ノート

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