Sodium Bicarbonate → (2Z)-3-Amino-2-cyano-4-ethyl-2-hexene
反応式
[NH2:1]/[C:2](/[CH:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[C:3](/[C:7]#[N:8])\[C:4](Cl)=O.C([O-])(O)=O.[Na+]>C(#N)C.O>[NH2:1]/[C:2](/[CH:9]([CH2:10][CH3:11])[CH2:12][CH3:13])=[C:3](\[C:7]#[N:8])/[CH3:4]参加物
5
反応条件
- 温度
- 25 °C
実験手順
3 g (15 mmol) of (2Z)-3-amino-2-cyano-4-ethyl-2-hexenoyl chloride dissolved in acetonitrile were added dropwise to a solution of 2.6 g (30 mmol) NaHCO3 in water. The solution was stirred at 25° C. for 30 min, then concentrated to dryness and the residue was taken up in methanol. The precipitate was seperated and the filtrate concencentrated to dryness again. The residue was dissolved in water and saturated KHSO4-solution was added. Filtration of the precipitate gave 2 g of the title compound (73% of theory) as a colorless solid (m. p. 150° C.)
後処理
- concentrationconcentrated to dryness
- customThe precipitate was seperated
- dissolutionThe residue was dissolved in water
- additionsaturated KHSO4-solution was added
- filtrationFiltration of the precipitate
出典と根拠
- ORDレコード
- ord-12016601758e4ca2949e51d73b61092e
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851411B2
反応ノート
読み込み中…