4-Fluoro-3-nitrobenzoic acid → 3-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acid

HRID 2262732ノート

反応式

HRID 2262732 の反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[C:8]([NH2:12])[CH:9]=[CH:10][CH:11]=1.F[C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C:15]=1[N+:23]([O-:25])=[O:24]>CN1C(=O)CCC1.O>[N+:23]([C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:14]=1[NH:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[CH:7]=1)[C:18]([OH:20])=[O:19])([O-:25])=[O:24]

参加物

5

反応物 2

HCID 679874-Fluoro-3-nitrobenzoic acidHCID 110193903-(1,3-Thiazol-2-yl)aniline

生成物 1

HCID 575722503-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acid収率 83.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

To a solution of 3-thiazol-2-yl-phenylamine (14.0 g, 79 mmol) in anhydrous NMP (50 ml) was added 4-fluoro-3-nitrobenzoic acid (15.0 g, 127 mmol). The resultant mixture was stirred at 90° C. over night. The cooled reaction cake was suspended in water and the solid was filtered off, washed with water and dried in the air to afford the desired product (22.5 g, 83%).

後処理

  1. customThe cooled reaction cake
  2. filtrationthe solid was filtered off
  3. washwashed with water
  4. customdried in the air

出典と根拠

ORDレコード
ord-6e4db7c9b4af47d48f91526c47b2ec4b
出典データセット
uspto-grants-2010_12
特許番号
US07851490B2

反応ノート

読み込み中…