Hydrochloric Acid → 1-(4-Phenyl-1,3-oxazol-2-yl)piperazine

HRID 2262901ノート

反応式

HRID 2262901 の反応式
[C:1]1([C:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>O1CCCC1.CO.C(OCC)(=O)C>[C:1]1([C:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[O:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 68777431Tert-butyl 4-(4-phenyl-1,3-oxazol-2-yl)piperazine-1-carboxylate

生成物 1

HCID 687757351-(4-Phenyl-1,3-oxazol-2-yl)piperazine収率 90.2%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of tert-butyl 4-(4-phenyl-1,3-oxazol-2-yl)piperazine-1-carboxylate (590 mg, 1.79 mmol) in tetrahydrofuran (4 ml) and methanol (4 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (4 ml), and the mixture was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure. The residue was poured to an aqueous 1 N sodium hydroxide solution (10 ml) and extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give 370 mg (90.0%) of the desired product as an oil.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. additionThe residue was poured to an aqueous 1 N sodium hydroxide solution (10 ml)
  3. extractionextracted with chloroform
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-27bd0f892f104f3793209c30ee1a4cde
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

反応ノート

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