2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride → 2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine
反応式
Cl.[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:9]1[S:13][N:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:10]=1>[OH-].[Na+]>[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:9]1[S:13][N:12]=[C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:10]=1参加物
3
実験手順
To 2-methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride (500 mg, 1.68 mmol) was added an aqueous 1N sodium hydroxide solution (10 ml) and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (438 mg, 100%) as oil.
後処理
- extractionthe mixture was extracted with chloroform
- dry with materialThe extract was dried over anhydrous magnesium sulfate
- distillationthe solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-6971592717bf4aa88bc8b51c68a39626
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851473B2
反応ノート
読み込み中…