Sodium Hydroxide → 1-(4-Phenyl-2-thienyl)piperazine

HRID 2263054ノート

反応式

HRID 2263054 の反応式
[C:1]1([C:7]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OCC)=O)[CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:7]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 68776928Ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate

生成物 1

HCID 687773121-(4-Phenyl-2-thienyl)piperazine収率 88.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate (350 mg, 1.11 mmol), an aqueous 8N sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 100° C. for 3 hours, and the solvent was distilled off under reduced pressure. The residue was poured into water and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (240 mg, 88.9%) as an oil.

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionThe residue was poured into water
  3. extractionthe mixture was extracted with chloroform
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-bfd9f8f126d74528a7d5c78541ca744c
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

反応ノート

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