Water → Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl ester

HRID 2263175ノート

反応式

HRID 2263175 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[F:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14]

参加物

5

反応物 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27374492-Bromo-2'-fluoroacetophenone

生成物 1

HCID 18526224Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl ester収率 95.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-bromo-1-(2-fluorophenyl)ethanone (5.00 g, 23.0 mmol) and potassium thiocyanate (2.24 g, 23.0 mmol) in ethanol (50 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (60 ml) was poured into the reaction solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (4.29 g, 95.5%) as a solid.

後処理

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-96725ae2fc564cedb3af24ca0bc94c03
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

反応ノート

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