Water → 2-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl thiocyanate
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[S-:15][C:16]#[N:17].[K+].O>C(O)C>[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)[CH2:2][S:15][C:16]#[N:17]参加物
5
実験手順
A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (7.10 g, 26.6 mmol) and potassium thiocyanate (2.58 g, 26.6 mmol) in ethanol (70 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (70 ml) was poured to the reaction mixture, and crystals were collected by filtration, and washed with water to give 3.88 g (59.5%) of the desired product as a solid.
後処理
- filtrationwere collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-821561c3238e42f4b1b1a03869e5e1dd
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07851473B2
反応ノート
読み込み中…