Pyridine → HCID 21408261、化合物

HRID 2263361

反応式

HRID 2263361 の反応式
[C:1]1([C:7]2[NH:8][C:9](=O)[O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:9]1[O:10][CH:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1

参加物

4

反応物 3

HCID 1049PyridineHCID 24813Phosphorus oxychlorideHCID 1186694-Oxazolin-2-one, 4-phenyl-

生成物 1

HCID 21408261HCID 21408261、化合物収率 15.7%

反応条件

温度
100 °C

実験手順

To a solution of 4-phenyl-1,3-oxazol-2(3H)-one (1.00 g, 62.0 mmol) in phosphorus oxychloride (18 ml) was added pyridine (0.974 ml, 12.0 mmol), and the mixture was stirred at 100° C. for 1 hour and 20 minutes. The solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1) to give 176 mg (15.7%) of the desired product as a solid.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1)

出典と根拠

ORDレコード
ord-5090c86d84594faf94a90ff756da590d
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

関連ノート

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