Iodine → 5-Iodo-3-methylpyridin-2-amine

反応式

[CH3:1][C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.[I:14](O)(=O)(=O)=O.II.[O-]S([O-])(=S)=O.[Na+].[Na+]>O.CC(O)=O>[I:14][C:6]1[CH:7]=[C:2]([CH3:1])[C:3]([NH2:8])=[N:4][CH:5]=1

参加物

反応物 5

HCID 807Iodine

HCID 1118Sulfuric Acid

HCID 153472-Amino-3-methylpyridine

HCID 24477Sodium Thiosulfate

HCID 65185Metaperiodic acid

生成物 1

HCID 9595865-Iodo-3-methylpyridin-2-amine収率 174.9%

試薬・触媒・溶媒 2

反応条件

温度: 80 °C

実験手順

To a solution of 3-methyl-2-pyridineamine (10 g) in a mixed solution of AcOH (60 mL), water (12 mL), and sulfuric acid (4.2 mL) was added periodic acid dehydrate (4.22 g) and iodine (9.39 g), and the mixture was heated at 80° C. for 2 hours. The reaction mixture was poured into 5% Na2S2O3 aq solution and extracted with ether. The organic layer was washed with 1N NaOH aq solution and brine, and dried over Na2SO4. The solvent was removed in vacuo and obtained residual solid was recrystallized with EtOH to give 5-iodo-3-methyl-2-pyridinamine (9.00 g) as pale yellow powder.