Water → HCID 59595965、化合物

HRID 2264189ノート

反応式

HRID 2264189 の反応式
[N+:1]([C:4]1[C:5]([NH2:15])=[N:6][C:7]([C:10]2[O:11][CH:12]=[CH:13][N:14]=2)=[CH:8][CH:9]=1)([O-:3])=[O:2].[Br:16]N1C(=O)CCC1=O.O>CN(C)C=O>[Br:16][C:8]1[CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[C:5]([NH2:15])=[N:6][C:7]=1[C:10]1[O:11][CH:12]=[CH:13][N:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimide2 回HCID 59595967HCID 59595967、化合物

生成物 1

HCID 59595965HCID 59595965、化合物収率 101.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 3-nitro-6-(1,3-oxazol-2-yl)pyridin-2-amine (0.127 g, 0.62 mmol) in dimethylformamide (3 mL) at 0° C. was added N-bromosuccinimide (0.115 g, 0.65 mmol) and the mixture was warmed to room temperature. After 3 days, further N-bromosuccinimide (0.058 g, 0.33 mmol) was added and stirring was continued for 3 hours. The solution was poured into water and the precipitate was filtered, washed with water and dried to give the title compound (0.18 g, 70%) as a yellow solid.

後処理

  1. waitwas continued for 3 hours
  2. filtrationthe precipitate was filtered
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-fd0797c6586644569cfdcb39b1ad8343
出典データセット
uspto-grants-2010_12
特許番号
US07855202B2

反応ノート

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