8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene → 8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane

HRID 2264283ノート

反応式

HRID 2264283 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[CH2:19][CH2:18][C:13]2([O:17][CH2:16][CH2:15][O:14]2)[CH2:12][CH:11]=1>CO.C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH:10]1[CH2:11][CH2:12][C:13]2([O:14][CH2:15][CH2:16][O:17]2)[CH2:18][CH2:19]1

参加物

5

反応物 1

HCID 574243608-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene

生成物 1

HCID 574243618-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene in methanol (240 mL) and ethyl acetate (5 mL) was treated with 10% palladium on carbon (7.0 g) and stirred under an atmosphere of hydrogen gas (40 psi) overnight. The reaction mixture was filtered over Celite. The filtrate was concentrated and chromatographed (silica gel, gradient 5-7% ethyl acetate in hexane) to yield the title compound.

後処理

  1. filtrationThe reaction mixture was filtered over Celite
  2. concentrationThe filtrate was concentrated
  3. customchromatographed (silica gel, gradient 5-7% ethyl acetate in hexane)

出典と根拠

ORDレコード
ord-b19d73fed1944897b28758c1d1799f59
出典データセット
uspto-grants-2010_12
特許番号
US07855206B2

反応ノート

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