HCID 68967238、化合物 → 2-(pyrrolidin-1-ylmethyl)aniline

HRID 226464ノート

反応式

HRID 226464 の反応式
C([CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-])=O)C>[Pd].CO>[N:4]1([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH2:5][CH2:6][CH2:7][CH2:3]1

参加物

4

反応物 1

HCID 68967238HCID 68967238、化合物

生成物 1

HCID 2643112-(pyrrolidin-1-ylmethyl)aniline収率 115.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of ethyl 1-(2-nitrobenzyl)pyrrolidine (1.90 g) and 10% palladium on carbon (200 mg) in methanol (40 mL) was hydrogenated at ambient temperature. After completion of the reaction, the catalyst in the reaction mixture was removed by filtration. The solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform/methanol=20/1 v/v) to give [2-(1-pyrrolidinylmethyl)phenyl]amine (1.65 g) as a pale yellow solid.

後処理

  1. customwas hydrogenated at ambient temperature
  2. customAfter completion of the reaction
  3. customthe catalyst in the reaction mixture was removed by filtration
  4. customThe solvent was evaporated in vacuo
  5. customThe residue was purified by silica gel column chromatography (chloroform/methanol=20/1 v/v)

出典と根拠

ORDレコード
ord-6edb1bc5f79b4f11b8fe30c71c1e594f
出典データセット
uspto-grants-2009_07
特許番号
US07557127B2

反応ノート

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