HCID 59596691、化合物 → HCID 59596702、化合物

HRID 2264827ノート

反応式

HRID 2264827 の反応式
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[CH:14]=[CH:13][C:12]([C@@H:15]3[N:19]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:18]([C:27]([O:29][CH3:30])=[O:28])[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:1]1([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C@@H:15]3[N:19]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:18]([C:27]([O:29][CH3:30])=[O:28])[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 59596691HCID 59596691、化合物

生成物 1

HCID 59596702HCID 59596702、化合物収率 92%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-{4-[(E)-2-phenylethenyl]phenyl}-1,2-pyrrolidinedicarboxylate (D79, 50 mg, 0.12 mmol) in methanol was added palladium (10 mg, 10 wt. % dry basis on activated carbon) and the mixture was stirred under hydrogen atmosphere (1 atm) for 4 h. A further addition of catalyst (20 mg) was required before the reaction was complete (as shown by HPLC). The catalyst was filtered off, the solvent removed under reduced pressure affording the title compound as a colourless oil (45 mg, 92%). Rt (HPLC): 7.04 min; MS: (ES/+) m/z: 432 [M+Na] C25H31NO4 requires 409.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-4fb85bf45e5c414fa35ef9af2c9fe9c4
出典データセット
uspto-grants-2010_12
特許番号
US07855218B2

反応ノート

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