3-Amino-5-fluorobenzotrifluoride → 2-[4'-Chloro-5-(3-fluoro-5-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester

HRID 226540

反応式

HRID 226540 の反応式
[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([C:30]([F:33])([F:32])[F:31])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:35][C:36]1[CH:37]=[C:38]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[NH2:39]>>[CH3:1][O:2][C:3](=[O:34])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([C:30]([F:33])([F:31])[F:32])[CH:24]=2)[CH:12]=[C:13]([NH:39][C:38]2[CH:40]=[C:41]([C:43]([F:44])([F:45])[F:46])[CH:42]=[C:36]([F:35])[CH:37]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

参加物

3

反応物 2

HCID 27359133-Amino-5-fluorobenzotrifluorideHCID 577549642-(4'-Chloro-5-trifluoromethanesulfonyloxy-3'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester

生成物 1

HCID 577550052-[4'-Chloro-5-(3-fluoro-5-trifluoromethyl-phenylamino)-3'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester収率 28%

実験手順

The title compound was prepared in 28% yield from 2-(4′-chloro-5-trifluoromethanesulfonyloxy-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester and 3-fluoro-5-(trifluoromethyl)aniline under the conditions described in Example 37, step (b). Mass spectrum (ES-, m/z): 560, 562 (M−H);

出典と根拠

ORDレコード
ord-5bd264eeef9d415dbff4b38bb0b2fed6
出典データセット
uspto-grants-2009_07
特許番号
US07557244B2

関連ノート

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