HCID 60135720、化合物 → HCID 60135712、化合物
反応式
[CH3:1][O:2][C:3](=[O:25])[CH:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14](=[O:24])[CH2:15][O:16]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:5]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:25])[CH:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14](=[O:24])[CH2:15][OH:16])=[CH:9][CH:8]=1)[CH3:5]参加物
4
実験手順
2-[4-(2-Benzyloxy-acetoxy)-phenoxy]-propionic acid methyl ester 15 (13 grams, 37.79 mmol) is dissolved in methanol (100 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 10 grams) added and the mixture stirred under an atmosphere of hydrogen (4 Kg) for 48 hours. The catalyst is removed by filtration and distilled off the methanol. The crude 16 can be purified by column chromatography on silica gel using chloroform:Ethyl acetate.
後処理
- customThe catalyst is removed by filtration
- distillationdistilled off the methanol
- customThe crude 16 can be purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-bacce61271b8477da01ad8e0da05c0b5
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07858077B2
反応ノート
読み込み中…