Aluminium lithium hydride → HCID 86625537、化合物
反応式
CON(C)[C:4](=[O:20])[C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[N:7][C:6]=1[CH2:15][CH2:16][CH2:17][O:18][CH3:19].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH3:19][O:18][CH2:17][CH2:16][CH2:15][C:6]1[C:5]([CH:4]=[O:20])=[CH:10][CH:9]=[C:8]([C:11]([F:12])([F:14])[F:13])[N:7]=1参加物
4
実験手順
N-Methoxy-2-(3-methoxy-propyl)-N-methyl-6-trifluoromethyl-nicotinamide (156 mg, 0.509 mmol) was reacted with 1M-LAH in THF solution to give 2-(3-methoxy-propyl)-6-trifluoromethyl-pyridine-3-carbaldehyde quantitatively as oil. The crude product was used directly in the following reaction. 2-(3-Methoxy-propyl)-6-trifluoromethyl-pyridine-3-carbaldehyde was reacted with methyl(triphenylphosphoranylidene)acetate (204 mg, 0.61 mmol) to give 3-[2-(3-methoxy-propyl)-6-trifluoromethyl-pyridin-3-yl]-acrylic acid methyl ester (124 mg, 80%).