2-Propanethiol → 3-(2-Isopropylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid
反応式
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[CH3:17][CH:18]([SH:20])[CH3:19].[H-].[Na+]>>[CH:18]([S:20][C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1)([CH3:19])[CH3:17]参加物
4
実験手順
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (245 mg, 0.974 mmol) was reacted with 2-propanthiol (240 mg, 3.15 mmol) and sodium hydride (143 mg, 3.56 mmol) to afford the title compound (103 mg) after purification by column chromatography (Hex/EtOAc=2.5/1).
出典と根拠
- ORDレコード
- ord-2e6d13fe45764c3b919ebb84e24e2033
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07858621B2
反応ノート
読み込み中…