Propyl mercaptan → 3-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid
反応式
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[CH2:17]([SH:20])[CH2:18][CH3:19].[H-].[Na+]>>[CH2:17]([S:20][C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1)[CH2:18][CH3:19]参加物
4
実験手順
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (243 mg, 0.966 mmol) was reacted with propanthiol (229 mg, 3.01 mmol) and sodium hydride (145 mg, 3.62 mmol) to afford title compound (115 mg) after purification by column chromatography (Hex EtOAc=2/3).
出典と根拠
- ORDレコード
- ord-e2fdece70e554f36b9f05f95e76a3e8d
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07858621B2
反応ノート
読み込み中…