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HCID 59598570、化合物 → 5-(2-Isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidine-2,4-diamine

HRID 2266153
ノート
印刷プレビュー

反応式

HRID 2266153 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH:8]C=O)[C:5]([O:11][C:12]2[CH:17]=[C:16]([C:18]3[N:22]=[CH:21][O:20][N:19]=3)[C:15]([O:23][CH3:24])=[CH:14][C:13]=2[CH:25]([CH3:27])[CH3:26])=[CH:4][N:3]=1.NC1C(OC2C=C(C3N=CON=3)C(OC)=CC=2C(C)C)=CN=C(NC=O)N=1.C(NC1C(OC2C=C(C3N=CON=3)C(OC)=CC=2C(C)C)=CN=C(NC=O)N=1)=O>FC(F)(F)C(O)=O>[CH:25]([C:13]1[CH:14]=[C:15]([O:23][CH3:24])[C:16]([C:18]2[N:22]=[CH:21][O:20][N:19]=2)=[CH:17][C:12]=1[O:11][C:5]1[C:6]([NH2:8])=[N:7][C:2]([NH2:1])=[N:3][CH:4]=1)([CH3:27])[CH3:26]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 59598570HCID 59598570、化合物HCID 59598574N-[4-formylamino-5-(2-isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidin-2-yl]-formamideHCID 59598641N-[4-amino-5-(2-isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidin-2-yl]formamide

生成物 1

HCID 573296085-(2-Isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidine-2,4-diamine

試薬・触媒・溶媒 1

HCID 6422
Trifluoroacetic acid
溶媒

実験手順

A mixture of N-[2-amino-5-(2-isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidin-4-yl]formamide, N-[4-amino-5-(2-isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidin-2-yl]formamide and N-[4-formylamino-5-(2-isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidin-2-yl]-formamide (0.164 g) in trifluoroacetic acid (10 mL) was heated at reflux for 24 h. The mixture was then cooled and concentrated in vacuo. The residue was purified by flash chromatography (0-5% methanol in dichloromethane) to yield 76 mg of 5-(2-isopropyl-4-methoxy-5-[1,2,4]oxadiazol-3-yl-phenoxy)-pyrimidine-2,4-diamine as its trifluoroacetic acid salt. (M+H)+=343; MP 135-138.5° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 24 h
  3. temperatureThe mixture was then cooled
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by flash chromatography (0-5% methanol in dichloromethane)

出典と根拠

ORDレコード
ord-6026227b4c014f92b0f192ade3930db6
出典データセット
uspto-grants-2010_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07858632B2

反応ノート

読み込み中…

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