Sodium Hydroxide → 1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

HRID 2266407ノート

反応式

HRID 2266407 の反応式
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[CH:12]=2)[CH:10]=1)=[O:5])C.[OH-].[Na+]>CO>[Br:17][C:13]1[CH:12]=[C:11]([N:9]2[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[CH:8]2)[CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 161287541-(3-Bromo-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester

生成物 1

HCID 234449541-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

To a solution of 3 (0.5 g, 1.7 mmol) in methanol (25 mL) was added aqueous NaOH (2M; 4.3 mL) and the reaction mixture was stirred at 40° C. for 0.5 h. Methanol was removed in vacuo and the water layer acidified and extracted with ethyl acetate, dried, filtered and evaporated to dryness. The crude compound was used as such for the next step.

後処理

  1. customMethanol was removed in vacuo
  2. extractionextracted with ethyl acetate
  3. customdried
  4. filtrationfiltered
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-a05c09233d764bc3a16937b3089a19dd
出典データセット
uspto-grants-2010_12
特許番号
US07858649B2

反応ノート

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