p-Toluenesulfonic acid → 3-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol

HRID 2266430ノート

反応式

HRID 2266430 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][CH:16]([C:20](=O)[CH3:21])[C:17](=O)[CH3:18])=[CH:13][CH:12]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[C:20]([CH3:21])=[N:1][C:2]3[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([OH:9])[C:3]=3[C:17]=2[CH3:18])=[CH:13][CH:12]=1

参加物

4

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 14888033-[(4-Chlorophenyl)methyl]pentane-2,4-dioneHCID 30186673-Amino-5-methylphenol

生成物 1

HCID 1363463303-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol

反応条件

温度
160 °C

実験手順

A mixture of 3-amino-5-methylphenol (1.0 g), 3-(4-chlorobenzyl)pentane-2,4-dione (1.7 g) and toluene-4-sulfonic acid (0.30 g) was heated at 160° C. under nitrogen for 3 hours. The mixture was cooled to room temperature and the residue triturated with methanol to give title compound, 1.5 g.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. customthe residue triturated with methanol

出典と根拠

ORDレコード
ord-f1acf58de28a45b6a0f12da71a887aaa
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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