Methanol → [7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic Acid

HRID 2266450ノート

反応式

HRID 2266450 の反応式
C[O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]2[C:6]=1[C:7]([CH3:25])=[C:8]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[C:9]([CH3:16])=[N:10]2.CO.O.[OH-].[Li+]>C(O)(=O)C>[Cl:15][C:13]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:25])=[C:8]([CH2:17][C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)[C:9]([CH3:16])=[N:10]2)=[C:5]([CH2:4][C:3]([OH:26])=[O:2])[CH:14]=1

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 68782352[7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic Acid Methyl Ester

生成物 1

HCID 57742513[7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic Acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of [7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic acid methyl ester (0.24 g), methanol (10 mL), water (2.0 mL) and saturated aqueous lithium hydroxide solution (1.0 mL) was stirred at room temperature for 17 hours. The pH of the solution was adjusted to 5 by the addition of glacial acetic acid and the methanol removed under reduced pressure. The resulting precipitate was collected by filtration and washed with water. Crystallisation of the solid from ethyl, acetate gave title compound as a fluffy white solid, 0.16 g

後処理

  1. customthe methanol removed under reduced pressure
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customCrystallisation of the solid from ethyl, acetate

出典と根拠

ORDレコード
ord-fb659d0830a646f580525d3347b4a0ac
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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