Methanol → HCID 57742526、化合物

HRID 2266487ノート

反応式

HRID 2266487 の反応式
C[O:2][C:3](=[O:34])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8]([O:30][CH:31]([F:33])[F:32])=[C:9]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=1)[C:10]([CH2:17][CH3:18])=[N:11]2.CO.O.[OH-].[Li+]>C(O)(=O)C>[Cl:16][C:13]1[CH:14]=[CH:15][C:6]([O:5][CH2:4][C:3]([OH:34])=[O:2])=[C:7]2[C:12]=1[N:11]=[C:10]([CH2:17][CH3:18])[C:9]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([S:26]([CH3:29])(=[O:27])=[O:28])=[CH:24][CH:25]=1)=[C:8]2[O:30][CH:31]([F:32])[F:33]

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 68784880HCID 68784880、化合物

生成物 1

HCID 57742526HCID 57742526、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of [8-chloro-4-difluoromethoxy-2-ethyl-3-(4-methanesulfonylbenzyl)quinolin-5-yloxy]acetic acid methyl ester (0.10 g), methanol (5.0 mL), water (1.0 mL) and saturated aqueous lithium hydroxide solution (0.5 mL) was stirred at room temperature for 45 minutes. The pH of the solution was adjusted to 5 by the addition of glacial acetic acid and the methanol removed under reduced pressured. The residue was diluted with water (2.0 mL) and the resulting precipitate collected by filtration, washed with water and dried to afford title compound as a white solid, 0.075 g.

後処理

  1. customthe methanol removed
  2. additionThe residue was diluted with water (2.0 mL)
  3. filtrationthe resulting precipitate collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-0f36b0f3f24947b28985f5e7f6248457
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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