Methanol → HCID 57742519、化合物

HRID 2266542ノート

反応式

HRID 2266542 の反応式
C[O:2][C:3](=[O:35])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]2[C:7]=1[C:8]([O:31][CH:32]([F:34])[F:33])=[C:9]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:21]=1[Cl:30])[C:10]([CH2:17][CH3:18])=[N:11]2.CO.[OH-].[Li+].O>C(O)(=O)C>[Cl:30][C:21]1[CH:22]=[C:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:24]=[CH:25][C:20]=1[CH2:19][C:9]1[C:10]([CH2:17][CH3:18])=[N:11][C:12]2[C:7]([C:8]=1[O:31][CH:32]([F:34])[F:33])=[C:6]([O:5][CH2:4][C:3]([OH:35])=[O:2])[CH:15]=[CH:14][C:13]=2[F:16]

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 68781651HCID 68781651、化合物

生成物 1

HCID 57742519HCID 57742519、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of [3-(2-chloro-4-methanesulfonylbenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid methyl ester (1.0 g), methanol (38 mL), 5.0 M aqueous lithium hydroxide solution (0.8 mL) and water (1.6 mL) was stirred at room temperature for 35 minutes. The pH of the mixture was adjusted to 4 by the addition of glacial acetic acid and the solvent removed under reduced pressure. The residue was diluted with water (4.0 mL) and the solid collected by filtration, washed with water and dried to afford to title compound as a cream solid, 0.66 g.

後処理

  1. customthe solvent removed under reduced pressure
  2. additionThe residue was diluted with water (4.0 mL)
  3. filtrationthe solid collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-580e0936dfae41fb82e76c9b590d5afc
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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