Hydrochloric Acid → [3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester

HRID 2266634ノート

反応式

HRID 2266634 の反応式
[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]2[C:7]=1[C:8]([CH3:26])=[C:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:10](Cl)=[N:11]2.Cl>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]2[C:7]=1[C:8]([CH3:26])=[C:9]([CH2:18][C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[CH:10]=[N:11]2

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86631459[2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester

生成物 1

HCID 68782397[3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic Acid Methyl Ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

A mixture of [2-chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic acid methyl ester (0.20 g), palladium (10 wt. % on activated carbon, 0.020 g), ethanol (7.0 mL) and 1.0 M aqueous hydrochloric acid (1.5 mL) was stirred at 40° C. for 17 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washed with ethanol and the filtrate concentrated under reduced pressure to afford title compound, 0.18 g.

後処理

  1. filtrationThe mixture was filtered through hyflo
  2. washwashed with ethanol
  3. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d79f11246e754723bc265eecaede84c9
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

読み込み中…