反応式
[CH2:1]([C:3]1[N:4]([C:8]2[CH:9]=[C:10]([C:21]([OH:23])=O)[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)[CH:13]=2)[CH:5]=[CH:6][N:7]=1)[CH3:2].[N:24]1[CH:29]=[CH:28][N:27]=[CH:26][C:25]=1[CH:30]([NH2:32])[CH3:31]>>[N:24]1[CH:29]=[CH:28][N:27]=[CH:26][C:25]=1[CH:30]([NH:32][C:21]([C:10]1[CH:11]=[C:12]([C:14]2[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][CH:19]=2)[CH:13]=[C:8]([N:4]2[CH:5]=[CH:6][N:7]=[C:3]2[CH2:1][CH3:2])[CH:9]=1)=[O:23])[CH3:31]参加物
3
実験手順
5-(2-Ethyl-imidazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid was subject to the amide coupling reaction described in step 3 of Example 3, but replacing C-(5-methyl-pyrazin-2-yl)-methylamine with 1-pyrazin-2-yl-ethylamine, to give 5-(2-ethyl-imidazol-1-yl)-4′-methyl-biphenyl-3-carboxylic acid (1-pyrazin-2-yl-ethyl)-amide, MS (M+H)=412.
出典と根拠
- ORDレコード
- ord-96282cea1b474c03bcd09175464ff903
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07858654B2
関連ノート
読み込み中…