Trifluoroacetic acid → N-(pentan-3-yl)spiro[indene-1,4'-piperidine]-3-carboxamide
反応式
FC(F)(F)C(O)=O.[CH3:8][CH2:9][CH:10]([NH:13][C:14]([C:16]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:18]2([CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH:17]=1)=[O:15])[CH2:11][CH3:12]>ClCCl>[CH3:12][CH2:11][CH:10]([NH:13][C:14]([C:16]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:18]2([CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[CH:17]=1)=[O:15])[CH2:9][CH3:8]参加物
4
実験手順
Trifluoroacetic acid (5 mL) was added to a stirred solution of compound (F1) (0.60 g, 1.50 mmol) in dichloromethane (10 mL) and the solution was stirred at room temperature for 1 h. The solvent was removed under reduced pressure and dried under high vacuum for 18 h to provide N-(pentan-3-yl)spiro[indene-1,4′-piperidine]-3-carboxamide (F2) as an oil (0.62 g). LC/MS (10-90% over 3 min with 0.9% FA) m/z 299 (M+1) Rt 1.9 minutes.