Sodium Azide → 2-Azidopyridine

HRID 2267139ノート

反応式

HRID 2267139 の反応式
[N-:1]=[N+:2]=[N-:3].[Na+].[O-]S(C(F)(F)F)(=O)=O.F[N+:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CO>[N:1]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][N:14]=1)=[N+:2]=[N-:3]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 2724576Pyridinium, 1-fluoro-, 1,1,1-trifluoromethanesulfonate (1:1)

生成物 1

HCID 109644722-Azidopyridine収率 82.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
-78 °C

実験手順

Sodium azide (390 mg) was dissolved in 30 ml of methanol and cooled at −78° C., 6.0 ml of a methanolic solution of 740 mg of 1-fluoropyridinium triflate was dropped thereinto and the mixture was stirred for 4 hours. The solvent was evaporated in vacuo and the residue washed with 50 ml of diethyl ether to give 296 mg of the title compound in an ark oily crude product.

後処理

  1. customThe solvent was evaporated in vacuo
  2. washthe residue washed with 50 ml of diethyl ether

出典と根拠

ORDレコード
ord-53dca0e895a142b4bbc7fae9b0477e87
出典データセット
uspto-grants-2010_12
特許番号
US07858800B2

反応ノート

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