Ethyl [(1'-benzyl-[1,4']bipiperidinyl-4-yl)-tert-butoxycarbonyl-amino]-acetate → Ethyl([1,4']bipiperidinyl-4-yl-tert-butoxycarbonyl-amino)-acetate

反応式

[CH2:1]([O:3][C:4](=[O:33])[CH2:5][N:6]([CH:14]1[CH2:19][CH2:18][N:17]([CH:20]2[CH2:25][CH2:24][N:23](CC3C=CC=CC=3)[CH2:22][CH2:21]2)[CH2:16][CH2:15]1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH3:2].[H][H]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:33])[CH2:5][N:6]([CH:14]1[CH2:19][CH2:18][N:17]([CH:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)[CH2:16][CH2:15]1)[C:7]([O:9][C:10]([CH3:13])([CH3:11])[CH3:12])=[O:8])[CH3:2]

参加物

実験手順

A suspension of 1.30 g (2.83 mmol) ethyl[(1′-benzyl-[1,4′]bipiperidinyl-4-yl)-tert-butoxycarbonyl-amino]-acetate and 0.16 g 10% Pd/C in 25 mL EtOH was hydrogenated for 5 h at 50° C. and 50 psi hydrogen pressure. The catalyst was removed by suction filtering and the filtrate was evaporated to dryness. The product was obtained as a colourless oil, which was reacted further without purification.