Trifluoroacetic acid → 1-(2-Amino-ethyl)-5,5-dimethyl-imidazolidin-2-one
反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[C:14]([CH3:16])([CH3:15])[CH2:13][NH:12][C:11]1=[O:17])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][N:10]1[C:14]([CH3:15])([CH3:16])[CH2:13][NH:12][C:11]1=[O:17]参加物
4
実験手順
[2-(5,5-Dimethyl-2-oxo-imidazolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (450 mg, 1.75 mmol) was dissolved in DCM (5 mL) and TFA (1 mL) was added. The mixture was allowed to stand for 16 h, concentrated, and purified by SCX ion exchange chromatography to give the product as a yellow oil (256 mg, 93%).
後処理
- concentrationconcentrated
- custompurified by SCX ion exchange chromatography
出典と根拠
- ORDレコード
- ord-ce8254b17d3e4b90bdd9f6e65b5305cd
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07858785B2
反応ノート
読み込み中…