2-Chloro-1,1-dimethoxyethane → 2-(N-Methyl-N-phenylamino)thiazole

HRID 2267382

反応式

HRID 2267382 の反応式
[CH3:1][N:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([NH2:5])=[S:4].CO[CH:14](OC)[CH2:15]Cl>C1(C)C=CC=CC=1>[CH3:1][N:2]([C:3]1[S:4][CH:14]=[CH:15][N:5]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 609862-Chloro-1,1-dimethoxyethaneHCID 7236311-Methyl-1-phenylthiourea

生成物 1

HCID 234593752-(N-Methyl-N-phenylamino)thiazole

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 10 g (60 mmol) of N-methyl-N-phenylthiourea in 100 mL of toluene was treated with 7.2 mL (63 mmol) of chloroacetaldehyde dimethylacetal and heated at reflux for 12 h. The solvent was removed in vacuo and the residue purified by flash chromatography eluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane to deliver the title compound. MS (M+H)+ 191.

後処理

  1. temperatureheated
  2. temperatureat reflux for 12 h
  3. customThe solvent was removed in vacuo
  4. customthe residue purified by flash chromatography
  5. washeluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane

出典と根拠

ORDレコード
ord-c367ec944d73486e8c63d7a0c8109701
出典データセット
uspto-grants-2010_12
特許番号
US07858785B2

関連ノート

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