Hydrochloric Acid → Piperidin-4-yl pivalate

HRID 2267705ノート

反応式

HRID 2267705 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl>CO.[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:20])[C:16]([CH3:18])([CH3:17])[CH3:19])[CH2:10][CH2:9]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 668415652,2-Dimethyl-propionic acid 1-benzyl-piperidin-4-yl ester

生成物 1

HCID 57464983Piperidin-4-yl pivalate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of piperidine 51 (35.99 g, 130.7 mmol) in methanol is hydrogenated with Pd/C in the presence of one equivalent of HCl (104.5 ml, 130.7 mmol, 1.25M in MeOH). After filtration and evaporation, the crude is taken up in ether and washed with 1N—NaOH and brine. Drying, evaporation and distillation (0.08 mbar, 75-90 C) gave a colourless oil. Yield: 17.98 g (74%).

後処理

  1. filtrationAfter filtration and evaporation
  2. washwashed with 1N—NaOH and brine
  3. customDrying
  4. customevaporation and distillation (0.08 mbar, 75-90 C)
  5. customgave a colourless oil

出典と根拠

ORDレコード
ord-6331622090a44f008539bbb5c8ccca71
出典データセット
uspto-grants-2010_12
特許番号
US07858781B2

反応ノート

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