Diisopropylethylamine → 4-p-tolyloxy-1H-indole-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

4-p-tolyloxy-1H-indole-2-carboxylic acid (137) (850 mg, 3.2 mmol) and 4-amino-N-benzylpiperidine (605 mg, 3.2 mmol) are dissolved in 5 ml of DMF and after addition of TBTU (1.2 g, 3.5 mmol) and ethyldiisopropylamine (2.2 ml, 12.8 mmol) the mixture is stirred at room temperature for 2 h. Then the mixture is evaporated at high vacuum. The residue is dissolved in ethyl acetate and washed with saturated NaHCO3-solution and brine. The organic layers are dried over Na2SO4, filtrated and evaporated under reduced pressure.

1. customThen the mixture is evaporated at high vacuum
2. dissolutionThe residue is dissolved in ethyl acetate
3. washwashed with saturated NaHCO3-solution and brine
4. dry with materialThe organic layers are dried over Na2SO4
5. filtrationfiltrated
6. customevaporated under reduced pressure

ORDレコード

ord-cb6fdaeb13844b1fa4e722071a03280d

出典データセット

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07858781B2