Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine
反応式
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1参加物
4
実験手順
The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) was dissolved in HCl (16 mL, 0.5 N) and McOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.
後処理
- temperatureto reflux for 16 hours
- extractionextracted with EtOAc (3×25 mL)
出典と根拠
- ORDレコード
- ord-bfa284ed9e1e4d60b2189ca976242b82
- 出典データセット
- uspto-grants-2001_12
- 特許番号
- US06326381B1
反応ノート
読み込み中…