Water → 2-(8-Iodooctyl)-4,5,6,7-tetramethoxyindan

HRID 2268473

反応式

HRID 2268473 の反応式
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:22][C:21]2[C:16](=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[C:20]=2[O:23][CH3:24])[CH2:15]1)(=O)=O.[I-:31].[Na+].O>CC(C)=O>[I:31][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:22][C:21]2[C:16](=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[C:20]=2[O:23][CH3:24])[CH2:15]1

参加物

5

反応物 3

HCID 962WaterHCID 5238Sodium IodideHCID 183485438-(4,5,6,7-Tetramethoxyindan-2-yl)octyl methanesulfonate

生成物 1

HCID 183485412-(8-Iodooctyl)-4,5,6,7-tetramethoxyindan収率 96.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The mixture of 8-(4,5,6,7-tetramethoxyindan-2-yl)octyl methanesulfonate (2.36 g), sodium iodide (2.38 g) in acetone (20 ml) was heated under reflux for 3 hr. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with 5% aqueous sodium sulfite, water, and saturated aqueous sodium chloride, and dried. The solvent was removed in vacuo to yield the entitled compound (2.44 g) as an oil.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. extractionwas then extracted with ethyl acetate
  4. washThe organic layer was washed with 5% aqueous sodium sulfite, water, and saturated aqueous sodium chloride
  5. customdried
  6. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-12e43a8690a64c9db37601c105d348df
出典データセット
uspto-grants-2001_12
特許番号
US06326369B1

関連ノート

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