Sodium Iodide → Ethyl 4-(3-iodopropoxy)benzoate
反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1.[I-:17].[Na+]>CC(C)=O.O>[I:17][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1参加物
5
実験手順
The mixture of ethyl 4-(3-chloropropoxy)benzoate (26.5 g), sodium iodide (49.0 g) in acetone (300 ml) was heated under reflux for 24 hr. The reaction mixture was diluted with water and extracted with diethyl ether. The organic layer was washed with 5% aqueous sodium sulfite, water, saturated aqueous sodium chloride, and dried. The solvent was removed in vacuo to yield the entitled compound (34.4 g) as an oil.
後処理
- temperaturewas heated
- temperatureunder reflux for 24 hr
- extractionextracted with diethyl ether
- washThe organic layer was washed with 5% aqueous sodium sulfite, water, saturated aqueous sodium chloride
- customdried
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-958417d83ed94a4db4d810fec83bf7a6
- 出典データセット
- uspto-grants-2001_12
- 特許番号
- US06326369B1
反応ノート
読み込み中…