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Tert-Butylamine → N-(2-tert-Butylcarbamoyl-ethyl)-N-isopropyl-3-methyl-5-[2-(pyridin-4-ylamino)-ethoxy]-benzamide trifluoroacetate

HRID 2268687
ノート
印刷プレビュー

反応式

HRID 2268687 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]([N:11]([C:17](=[O:35])[C:18]1[CH:23]=[C:22]([O:24][CH2:25][CH2:26][NH:27][C:28]2[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=2)[CH:21]=[C:20]([CH3:34])[CH:19]=1)[CH2:12][CH2:13][C:14](O)=[O:15])([CH3:10])[CH3:9].C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.[C:69]([NH2:73])([CH3:72])([CH3:71])[CH3:70]>CN(C=O)C>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:69]([NH:73][C:14]([CH2:13][CH2:12][N:11]([CH:8]([CH3:9])[CH3:10])[C:17](=[O:35])[C:18]1[CH:23]=[C:22]([O:24][CH2:25][CH2:26][NH:27][C:28]2[CH:29]=[CH:30][N:31]=[CH:32][CH:33]=2)[CH:21]=[C:20]([CH3:34])[CH:19]=1)=[O:15])([CH3:72])([CH3:71])[CH3:70]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 6385Tert-ButylamineHCID 81531DiisopropylethylamineHCID 2733179PyBroPHCID 699505203-(Isopropyl-{3-methyl-5-[2-(pyridin-4-ylamino)-ethoxy]-benzoyl}-amino)-propionic acid trifluoroacetate

生成物 1

HCID 18349007N-(2-tert-Butylcarbamoyl-ethyl)-N-isopropyl-3-methyl-5-[2-(pyridin-4-ylamino)-ethoxy]-benzamide trifluoroacetate

試薬・触媒・溶媒

1
HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 3-(isopropyl-{3-methyl-5-[2-(pyridin-4-ylamino)-ethoxy]-benzoyl}-amino)-propionic acid trifluoroacetate (0.018 g) and PyBroP® (0.017 g) in DMF (1 ml) was added DIPEA (0.012 ml) followed by tert-butylamine (0.005 ml), after 1 min. The reaction mixture was stirred at room temperature for 18 h, and then concentrated under reduced pressure. The residue was subjected to preparative hplc and the title compound (0.009 g) was obtained as a colourless oil by concentration of the required fraction under reduced pressure and drying by repetitive addition of acetonitrile and concentration under reduced pressure.

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a60d6eef46df4b5db48e25393b485f13
出典データセット
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06326386B1

反応ノート

読み込み中…

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