Triphenylphosphine → HCID 18381616、化合物
反応式
[Br:1][CH:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH:12]([F:14])[F:13])=[CH:8][CH:9]=2)[C:4](=[O:15])[O:3]1.[C:16]1([P:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(#N)C>[Br-:1].[F:13][CH:12]([F:14])[O:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:2]([P+:22]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[O:3][C:4]2=[O:15]参加物
4
実験手順
Under N2, a solution of 3-bromo-6-difluoromethoxy-3H-isobenzofuran-1-one (6.2 g, 22.2 mmoles), prepared as described in example 95, in dry acetonitrile (30 ml) was added with triphenylphosphine (6.4 g, 24.4 mmoles). After 4 hours under reflux the mixture was dried to give a foam which was triturated in ethyl ether overnight, then filtered, washed with ethyl ether and dried to give 11.4 g of the title compound (yield: 95%).