Sodium borohydride → HCID 18334204、化合物
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([NH:17][CH:18]([C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[CH:21]=2)[CH3:19])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[C:11]1([CH:10]([NH:17][CH:18]([C:20]2[CH:21]=[C:22]([F:27])[CH:23]=[C:24]([F:26])[CH:25]=2)[CH3:19])[C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
In a similar manner to that described in Example (1b), a solution of isomer A of [(3-nitrophenyl)phenylmethyl]-[1-(3,5-difluorophenyl)ethyl]amine (900 mg) [prepared as described in step (a) above] in methanol (20 ml), nickel chloride hexahydrate (1.14 g) and sodium borohydride (363 mg) were reacted, to afford isomer A of the title compound (739 mg) as a pale yellow oil.