Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(3-methoxyphenyl)methyl]amine

HRID 2269438ノート

反応式

HRID 2269438 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[O:20][CH3:21])=O)[CH:6]=[CH:7][CH:8]=1.Cl.[F:23][C:24]1[CH:25]=[C:26]([CH:31]([NH2:33])[CH3:32])[CH:27]=[CH:28][C:29]=1[F:30].C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:23][C:24]1[CH:25]=[C:26]([CH:31]([NH:33][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:12]=2[O:20][CH3:21])[C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH3:32])[CH:27]=[CH:28][C:29]=1[F:30]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 183471131-(3,4-Difluorophenyl)ethan-1-amine hydrochlorideHCID 701892132-Methoxy-5-nitrophenyl 3-methoxyphenyl ketone

生成物 1

HCID 18334104N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(3-methoxyphenyl)methyl]amine収率 92.8%

試薬・触媒・溶媒 2

HCID 24193Titanium Tetrachloride触媒HCID 176Acetic Acid溶媒

実験手順

Following a similar procedure to that described in Example (1a), 600 mg of 2-methoxy-5-nitrophenyl 3-methoxyphenyl ketone, 809 mg of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 1.75 ml of triethylamine, 0.28 ml of titanium tetrachloride, 583 mg of sodium cyanoborohydride and 0.18 ml of acetic acid were reacted, to obtain 830 mg of the title compound as a yellow foamy solid.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-edc6aec86af149528e2a0491c8b65974
出典データセット
uspto-grants-2001_12
特許番号
US06329405B1

反応ノート

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