Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine

HRID 2269442ノート

反応式

HRID 2269442 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)=O)=[CH:5][CH:4]=1.Cl.[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH2:35])[CH3:34])[CH:29]=[CH:30][C:31]=1[F:32].C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH:35][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)[C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:34])[CH:29]=[CH:30][C:31]=1[F:32]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 18334221HCID 18334221、化合物HCID 183471131-(3,4-Difluorophenyl)ethan-1-amine hydrochloride

生成物 1

HCID 18334197N-[1-(3,4-Difluorophenyl)ethyl]-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine収率 93.9%

試薬・触媒・溶媒 2

HCID 24193Titanium Tetrachloride触媒HCID 176Acetic Acid溶媒

実験手順

Following a similar procedure to that described in Example (1a), 700 mg of 3,4-dimethoxy-5-nitrophenyl 4-methoxyphenyl ketone, 854 mg of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 1.84 ml of triethylamine, 0.29 ml of titanium tetrachloride, 616 mg of sodium cyanoborohydride and 0.19 ml of acetic acid were reacted, to obtain 950 mg of the title compound as a yellow oil.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-8decf6faa133429cb06d4c5da8fa6cd9
出典データセット
uspto-grants-2001_12
特許番号
US06329405B1

反応ノート

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