Triethylamine → 1-(3,5-difluorophenyl)ethyl-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine

HRID 2269444ノート

反応式

HRID 2269444 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)=O)=[CH:5][CH:4]=1.Cl.[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH2:35])[CH3:34])[CH:29]=[C:30]([F:32])[CH:31]=1.C(N(CC)CC)C.C([BH3-])#N.[Na+]>[Ti](Cl)(Cl)(Cl)Cl.C(O)(=O)C>[F:25][C:26]1[CH:27]=[C:28]([CH:33]([NH:35][CH:9]([C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([O:20][CH3:21])=[C:13]([O:22][CH3:23])[CH:12]=2)[C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:34])[CH:29]=[C:30]([F:32])[CH:31]=1

参加物

7

反応物 4

HCID 8471TriethylamineHCID 5003444Sodium cyanoborohydrideHCID 18334221HCID 18334221、化合物HCID 183470361-(3,5-Difluorophenyl)ethanamine hydrochloride

生成物 1

HCID 183470481-(3,5-difluorophenyl)ethyl-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine収率 91.4%

試薬・触媒・溶媒 2

HCID 24193Titanium Tetrachloride触媒HCID 176Acetic Acid溶媒

実験手順

Following a similar procedure to that described in Example (1a), 750 mg of 3,4-dimethoxy-5-nitrophenyl 4-methoxyphenyl ketone, 915 mg of 1-(3,5-difluorophenyl)ethylamine hydrochloride, 1.98 ml of triethylamine, 0.31 ml of titanium tetrachloride, 660 mg of sodium cyanoborohydride and 0.20 ml of acetic acid were reacted, to obtain 990 mg of the title compound as a yellow oil.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-5d6affbdf54448e796c7783a29a4bb76
出典データセット
uspto-grants-2001_12
特許番号
US06329405B1

反応ノート

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