Sodium borohydride → 3-{[1-(3,5-Difluorophenyl)ethylamino]-(4-ethoxyphenyl)methyl}phenylamine
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH3:30])=[CH:24][CH:23]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:23]=[CH:24][C:25]([O:28][CH2:29][CH3:30])=[CH:26][CH:27]=2)[C:13]2[CH:14]=[C:15]([NH2:19])[CH:16]=[CH:17][CH:18]=2)[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1参加物
4
実験手順
Following a reaction and purification procedure similar to those described in Example (59b), 1.39 g of N-[1-(3,5-difluorophenyl)ethyl]-N-[(4-ethoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 1.84 g of nickel chloride hexahydrate and 537 mg of sodium borohydride were reacted, to obtain 316 mg of isomer A and 531 mg of isomer B of the title compound as yellow oils, respectively.